• Curr Opin Pharmacol · Feb 2015

    Review

    How does ketamine elicit a rapid antidepressant response?

    • Ege T Kavalali and Lisa M Monteggia.
    • Department of Neuroscience, UT Southwestern Medical Center, Dallas, TX 75390-9111, USA; Department of Physiology, UT Southwestern Medical Center, Dallas, TX 75390-9111, USA. Electronic address: ege.kavalali@utsouthwestern.edu.
    • Curr Opin Pharmacol. 2015 Feb 1; 20: 35-9.

    AbstractA single sub-psychotomimetic dose of ketamine, an ionotropic glutamatergic n-methyl-D-aspartate (NMDA) receptor antagonist, produces a fast-acting antidepressant response in patients suffering from major depressive disorder. Depressed patients report alleviation of core symptoms within 2 h of a single low-dose intravenous infusion of ketamine with effects lasting up to 2 weeks. The rapidity of ketamine action implies that major symptoms of depression can be alleviated without substantial structural plasticity or circuit rewiring. Therefore, the ability of ketamine to exert a rapid effect provides a unique opportunity to elucidate the types of acute synaptic plasticity changes that can be recruited to counter depression symptoms.Copyright © 2014 Elsevier Ltd. All rights reserved.

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