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Hematol. Oncol. Clin. North Am. · Dec 2009
ReviewChronic immune thrombocytopenia in children: epidemiology and clinical presentation.
- Carolyn M Bennett and Michael Tarantino.
- Aflac Cancer Center and Blood Disorders Service, Emory University School of Medicine and Children's Healthcare of Atlanta, 5455 Meridian Mark Road, Suite 400, Atlanta, GA 30342, USA. carolyn.bennett@choa.org
- Hematol. Oncol. Clin. North Am. 2009 Dec 1; 23 (6): 1223-38.
AbstractImmune thrombocytopenic purpura (ITP) is one of the most common acquired bleeding disorders in children. Most children with ITP will have acute disease, self-limited thrombocytopenia that resolves completely within weeks or months, with or without therapy. A small subset of children with ITP has clinically significant disease with severe thrombocytopenia and/or bleeding that requires intervention. Treatment for these children is an ongoing clinical challenge, as few therapies offer long-term remission, and all have significant side effects and toxicities. This article focuses on the management of clinically significant chronic ITP in the pediatric population.
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