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Ugeskrift for laeger · Oct 2017
Review[Inhibition of the Janus kinase-signal transducer and activator of transcription is a new treatment modality of rheumatoid arthritis].
- Malte Frøling, Clara Mikkelsen, Peter Preben Eggertsen, Mette Stern, Anne van de Looij, and Bent Deleuran.
- bd@biomed.au.dk.
- Ugeskr. Laeg. 2017 Oct 30; 179 (44).
AbstractRheumatoid arthritis (RA) is a chronic inflammatory joint disease. The introduction of a new class of disease-modifying anti-rheumatic drugs, which work by inhibiting the Janus kinase-signal transducer and activator of transcription (JAK/STAT) pathway, has led to new possibilities for achieving remission of RA. Tofacitinib and baricitinib are both JAK/STAT inhibitors, which have shown efficacy in line with anti-tumour necrosis factor treatment. The side effects seem manageable, and up to now only increased risk of herpes zoster has raised consideration. JAK/STAT inhibitors create new possibilities for reaching low disease activity or remission for patients with RA.
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