• Keum Nae Kang, Tae Woong Kim, Jin Woo Koh, Han Byeol Oh, Jong-Uk Mun, Mi Sook Seo, and Young Uk Kim.
• Department of Anesthesiology and Pain Medicine, National Police Hospital, Seoul Department of Orthopaedic Surgery, Changwon Gyeongsang National University Hospital Department of Anesthesiology and Pain Medicine, Catholic Kwandong University of Korea College of Medicine, International St. Mary's Hospital, Incheon, Republic of Korea.
• Medicine (Baltimore). 2017 Jun 1; 96 (25): e7174.

RationaleTransforaminal epidural glucocorticoids administration is widely performed for the management of lumbosacral radiculopathy. However, it may worsen the condition of patients with type 2 diabetes mellitus (DM). Polydeoxyribonucleotide (PDRN) was recently noted as a substitute for glucocorticoids.Patient ConcernsA 44-year-old male patient was admitted to our pain clinic with symptoms of low back pain with severe pain and tingling sensation of left posterolateral leg. He had type 2 DM medicated with Glimepiride and Metformin. Blood glucose level was 367 mg/dL. He declined to use glucocorticoid.DiagnosesHe was diagnosed as left foraminal disc protrusion at L4-5, left subarticular disc protrusion at L5-S1.InterventionsFluoroscopically guided transforaminal epidural PDRN injections were carried out.OutcomesThe patient was followed up for more than 6 months and demonstrated good improvement in lumbosacral radiculopathy without any complications.LessonsThis is the first successful report on epidural injection of PDRN.

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