• Timothée Klopfenstein, N'dri Juliette Kadiane-Oussou, Pierre-Yves Royer, Lynda Toko, Vincent Gendrin, and Souheil Zayet.
• Infectious Diseases Department, Nord Franche-Comté Hospital, site de Belfort, 90016 Belfort, France. Electronic address: timothee.klopfenstein@hnfc.fr.
• Clin Res Hepatol Gastroenterol. 2020 Jun 1; 44 (3): 282-283.

AbstractIn a retrospective study in the Nord Franche-Comté hospital conducted between March 1st and March 17th 2020, and compared to the review of Li et al., diarrhea was a main symptom in patients with COVID-19. Out of the 114 patients, 55 (48%) had diarrhea; it was the fifth most common symptom. In the group of patients with diarrhea, the median age was 56 years (±18) and 32 (58%) were female. Only 2 patients (3.6%) had a past history of inflammatory bowel disease. Fifty-six percent of patients (n=30/54) were hospitalised. Diarrhea appeared 4.5 days (±1.8) after the onset of the first other symptoms in COVID-19. Of the 55 patients with diarrhea, 29 (52.7%) had at least one simultaneous gastrointestinal (GI) symptom other than diarrhea. Twenty-five patients (45.5%) had nausea, 19 patients (34.5%) had abdominal pain and 9 (16.3%) had vomiting. Myalgia, sore throat, sneezing and the other GI symptoms were statistically more frequent in the group with diarrhea than in the group without diarrhea (P<0.05).Copyright © 2020 Elsevier Masson SAS. All rights reserved.

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