• Joanne C Sierink, Teun P Saltzherr, Michael J R Edwards, Benn J A Beuker, Peter Patka, J C Carel Goslings, and REACT-2-studiegroep.
• Academisch Medisch Centrum, afd. Chirurgie, Trauma-unit, Amsterdam, the Netherlands.
• Ned Tijdschr Geneeskd. 2012 Jan 1;156(30):A4897.

BackgroundImmediate total body computed tomography (CT) scanning has become important in the early diagnostic phase of trauma care because of its high diagnostic accuracy. However, literature provides limited evidence whether immediate total body CT leads to better clinical outcome then conventional radiographic imaging supplemented with selective CT scanning in trauma patients. The aim of the REACT-2 trial is to determine the value of immediate total body CT scanning in trauma patients.DesignThe REACT-2 trial is an international, multicenter randomized clinical trial.MethodsAll participating trauma centers have a multi-slice CT scanner located in the trauma room or at the Emergency Department (ED). All adult, non-pregnant, severely injured trauma patients according to predefined criteria will be included. The intervention group will receive a contrast-enhanced total body CT scan (head to pelvis) during the primary survey. The control group will be evaluated according to local conventional trauma imaging protocols (based on ATLS guidelines) supplemented with selective CT scanning. Primary outcome will be in-hospital mortality. Secondary outcomes are differences in mortality and morbidity during the first year post trauma, several trauma work-up time intervals, radiation exposure, general health and quality of life at 6 and 12 months post trauma and cost-effectiveness.ConclusionThe REACT-2 trial is the first multicenter randomized clinical trial that will provide evidence on the value of immediate total body CT scanning during the primary survey of severely injured trauma patients.

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