• J. Neurol. Sci. · Dec 2011

    Review

    Vitamin D-gene interactions in multiple sclerosis.

    • Antonio J Berlanga-Taylor, Giulio Disanto, George C Ebers, and Sreeram V Ramagopalan.
    • Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford, OX3 7BN, UK.
    • J. Neurol. Sci. 2011 Dec 15; 311 (1-2): 32-6.

    AbstractVitamin D has been studied for over a century and its functions related to calcium homeostasis are well established. Over the last 30 years or so it has become increasingly clear that it has a wider role in physiology and, importantly, also in disease. Vitamin D deficiency has been linked to multiple sclerosis (MS); however the molecular mechanisms of this association were poorly understood. Recent technological advances have provided major insights as to how vitamin D may exert its role, particularly through the actions of the vitamin D receptor (VDR). In this review we aim to highlight the importance of the interaction between vitamin D and MS associated genes which provide a biological basis for the association between vitamin D and MS risk.Copyright © 2011 Elsevier B.V. All rights reserved.

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