• J Biopharm Stat · Jan 2017

    Multiple comparisons with two controls for ordered categorical responses.

    • Ping Yang, Hung CheungSiuSa Department of Statistics , The Chinese University of Hong Kong , Hong Kong , China., and Wai-Yin Poon.
    • a Department of Statistics , The Chinese University of Hong Kong , Hong Kong , China.
    • J Biopharm Stat. 2017 Jan 1; 27 (1): 111-123.

    AbstractIn clinical studies, ordered categorical responses are common. To compare the efficacy of several treatments with a control for ordinal responses, the normal latent variable model has recently been proposed. This approach conceptualizes the responses as manifestations of an underlying continuous normal variable. In this article, we extend this idea to develop the multiple comparison method for use when there are two controls in the clinical trial. The proposed method is constructed such that the familywise type I error rate is controlled at a prespecified level. In addition, for a given level of test power, the procedure to evaluate the required sample size is provided. The proposed testing procedure is also illustrated by an example from a clinical study.

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