• Gan To Kagaku Ryoho · Jan 2005

    Multicenter Study Clinical Trial

    [VNCOP-B (etoposide, mitoxantrone, cyclophosphamide, vincristine, predonisolone, bleomycin) therapy in elderly patients with aggressive non-Hodgkin lymphoma--a study of efficacy and safety, final report].

    • Kazuyoshi Ishii, Yoshihisa Yamamoto, Takashi Shigeki, Hitoshi Kitayama, Kunio Hayashi, Asao Hirose, Tadanobu Ohta, Atsuko Mugitani, Hiroko Fujino, Toshiya Yagi, Manabu Hirai, Hirofumi Teshima, Tatsuya Katsurada, Fumiaki Urase, and Hiroyuki Kitajima.
    • Dept. of Hematology, Kishiwada City Hospital.
    • Gan To Kagaku Ryoho. 2005 Jan 1; 32 (1): 39-44.

    AbstractWe experienced the VNCOP-B (etoposide, mitoxantrone, cyclophosphamide, vincristine, predonisolone, bleomycin) combination regimen for the treatment of elderly patients with aggressive non-Hodgkin lymphoma (NHL) in a multicenter study by 6 collaborative institutions. Patients were previously untreated > or = 60 years of age and received prophylactic G-CSF. Twenty patients entered this trial, and all of them were evaluated for feasibility, toxicity, and efficacy. The complete remission rate was 75.0%, with a 100% overall response rate; overall survival (OS) rate at 3 years was 79.1% (median follow up 761.5 days), with a 60.7% progression-free 3-year survival (PFS) rate (median follow-up 600.0 days). Our trial was promising and well-tolerated. According to IPI, high/high-intermediate risk was associated with significantly worse OS and PFS than low/low-intermediate risk (2-year OS: 51.8% versus 100.0%, p=0.0118; 2-year PFS: 33.3% versus 80.0%, p=0.0125). Grade 3/4 infections occurred in 3 patients, but no patients experienced it with predonisolone reduced.

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