• Curr Opin Invest Dr · May 2008

    Review

    XToll, a recombinant chaperonin 10 as an anti-inflammatory immunomodulator.

    • Willem van Eden.
    • University of Utrecht, Institute of Infectious Diseases and Immunology, Yalelaan 1, 3584CL Utrecht, The Netherlands. w.vaneden@uu.nl
    • Curr Opin Invest Dr. 2008 May 1; 9 (5): 523-33.

    AbstractCBio Ltd, under license from the University of Queensland, is developing a recombinant form of chaperonin 10, known as XToll, for the potential anti-inflammatory treatment of rheumatoid arthritis, psoriasis and multiple sclerosis. All three indications have been evaluated in phase IIa clinical trials. By May 2005, a phase IIa trial for Crohn's disease had been terminated due to slow recruitment. The company has not disclosed plans for future development for this indication.

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