• Gavin Churchyard, Vicky Cárdenas, Violet Chihota, Kathy Mngadi, Modulakgotla Sebe, William Brumskine, Neil Martinson, Getnet Yimer, Shu-Hua Wang, Alberto L Garcia-Basteiro, Dinis Nguenha, LeeAnne Masilela, Zainab Waggie, Susan van den Hof, Salome Charalambous, Frank Cobelens, Richard E Chaisson, Alison D Grant, Katherine L Fielding, and WHIP3TB Study Team.
• The Aurum Institute, Parktown, South Africa, Vanderbilt University, Nashville, Tennessee, and University of the Witwatersrand, Johannesburg, South Africa (G.C.).
• Ann. Intern. Med. 2021 Oct 1; 174 (10): 1367-1376.

BackgroundTuberculosis preventive therapy for persons with HIV infection is effective, but its durability is uncertain.ObjectiveTo compare treatment completion rates of weekly isoniazid-rifapentine for 3 months versus daily isoniazid for 6 months as well as the effectiveness of the 3-month rifapentine-isoniazid regimen given annually for 2 years versus once.DesignRandomized trial. (ClinicalTrials.gov: NCT02980016).SettingSouth Africa, Ethiopia, and Mozambique.ParticipantsPersons with HIV infection who were receiving antiretroviral therapy, were aged 2 years or older, and did not have active tuberculosis.InterventionParticipants were randomly assigned to receive weekly rifapentine-isoniazid for 3 months, given either annually for 2 years or once, or daily isoniazid for 6 months. Participants were screened for tuberculosis symptoms at months 0 to 3 and 12 of each study year and at months 12 and 24 using chest radiography and sputum culture.MeasurementsTreatment completion was assessed using pill counts. Tuberculosis incidence was measured over 24 months.ResultsBetween November 2016 and November 2017, 4027 participants were enrolled; 4014 were included in the analyses (median age, 41 years; 69.5% women; all using antiretroviral therapy). Treatment completion in the first year for the combined rifapentine-isoniazid groups (n = 3610) was 90.4% versus 50.5% for the isoniazid group (n = 404) (risk ratio, 1.78 [95% CI, 1.61 to 1.95]). Tuberculosis incidence among participants receiving the rifapentine-isoniazid regimen twice (n = 1808) or once (n = 1802) was similar (hazard ratio, 0.96 [CI, 0.61 to 1.50]).LimitationIf rifapentine-isoniazid is effective in curing subclinical tuberculosis, then the intensive tuberculosis screening at month 12 may have reduced its effectiveness.ConclusionTreatment completion was higher with rifapentine-isoniazid for 3 months compared with isoniazid for 6 months. In settings with high tuberculosis transmission, a second round of preventive therapy did not provide additional benefit to persons receiving antiretroviral therapy.Primary Funding SourceThe U.S. Agency for International Development through the CHALLENGE TB grant to the KNCV Tuberculosis Foundation.

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