• Alastair Ewen, Robin G Cox, Sîon A Davies, Jeremy B Luntley, Yair Rubin, Gordon H Fick, and Bevin B Bart.
• Division of Pediatric Anesthesia, Alberta Children's Hospital at University of Calgary, 1820 Richmond Road SW, Calgary, Alberta T2T 5C7, Canada.
• Can J Anaesth. 2005 May 1; 52 (5): 524-9.

PurposeBilateral flexion-induced ankle clonus has been proposed as a test of spinal cord integrity during anesthesia for scoliosis surgery. The purpose of this study was to establish the reliability of this test in normal children emerging from volatile anesthesia. A secondary objective was to determine if there was a difference in the validity of this test with either sevoflurane or isoflurane anesthesia.MethodsIn a randomized, prospective blinded clinical trial, 32 healthy children aged three to 13 yr, were randomized to receive either isoflurane (Group I, n = 15) or sevoflurane (Group S, n = 17) for maintenance of anesthesia during dental restorative surgery. During emergence, an observer, blinded to group allocation, recorded ankle clonus scores (number of beats to a maximum of 5 on each side) at 60-sec intervals until tracheal extubation. End-tidal anesthetic concentration was measured contemporaneously.ResultsNon-sustained ankle clonus was elicited in a majority of children during emergence: 13 (87%) patients in Group I and 15 (88%) in Group S demonstrated at least non-sustained or unilateral clonus. However, bilateral sustained (> 5 beats.min(-1)) ankle clonus occurred in only four (27%) patients in Group I and four (24%) patients in Group S (P = 0.83).ConclusionWe conclude that the specificity of the ankle clonus test is too low to be clinically useful as a measure of spinal cord integrity in children, both when isoflurane and sevoflurane are used as the primary anesthetic agent.

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