• Haifeng Wang, Sen Jia, Yuchou Chang, Yanjie Zhu, Chao Zou, Ye Li, Xin Liu, Hairong Zheng, and Dong Liang.
• Paul C. Lauterbur Research Centre for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, People's Republic of China. Co-First/Equal Authorship.
• Phys Med Biol. 2019 Jul 18; 64 (14): 14NT01.

AbstractTo improve the reconstruction condition and alleviate the noise amplification of GRAPPA reconstruction by aggregating the phase conjugated and nonlinear kernel mapped coils with the original physical coil. Nonlinear GRAPPA (NL-GRAPPA) is a kernel-based non-iterative approach which can reduce noise-induced error in GRAPPA reconstruction. And virtual conjugate coil (VCC) embeds the conjugate symmetric property of k-space into GRAPPA data synthesis to improve reconstruction condition. This work proposed NL-VCC-GRAPPA to jointly utilize the nonlinear mapped virtual coil and phase conjugated virtual coil to further reduce noise amplification in parallel imaging. In vivo static and dynamic 2D imaging accelerated by uniform undersampling schemes were performed to evaluate the proposed method in terms of visual image quality, root-mean-square-error (RMSE), and geometry factor (g-factor). The effects of acceleration factors, calibration data size and kernel shape on the proposed model were also separately analyzed and discussed. The proposed method illustrated improved visual image quality evidenced by reduced retrospective RMSE and prospective g-factor comparing with conventional GRAPPA and the recently proposed iterative SENSE-LORAKS reconstructions. Although a larger amount of calibration data and smaller kernel size were required to stabilize the calibration of fourfold extended kernel for the proposed method, it was non-iterative and relatively insensitive to parameter adjustment in the applications. The proposed NL-VCC-extension to conventional GRAPPA brings visible improvements for imaging scenarios accelerated by the widely available uniform undersampling schemes in a practically efficient manner without iteration.

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