• Thomas Radtke, Helge Hebestreit, Milo A Puhan, and Susi Kriemler.
• Epidemiology, Biostatistics and Prevention Institute, University of Zürich, Zurich, Switzerland. Electronic address: thomas.radtke@uzh.ch.
• J. Cyst. Fibros. 2017 Nov 1; 16 (6): 744-751.

BackgroundWe aimed to characterize the cardiopulmonary response during a 1-min sit-to-stand (STS) test and compare peak exercise cardiorespiratory variables to a maximal cardiopulmonary exercise test (CPET) in cystic fibrosis (CF). We further aimed to assess the validity of the STS power index (PowerSTS) as a measure of exercise capacity.MethodsFifteen adult CF patients performed spirometry, CPET and the 1-min STS test with respiratory gas analysis.ResultsPeak-exercise cardiorespiratory variables during the 1-min STS test correlated strongly (r=0.69-0.98) with those measured during the CPET. Oxygen uptake, carbon dioxide production, heart rate, ventilation, and tidal volume at peak exercise were 24%, 26%, 9%, 10% and 21% lower in the 1-min STS test, while respiratory frequencies were 14% higher. PowerSTS showed strong to very strong correlations with CPET-derived absolute peak oxygen uptake and maximal workload.ConclusionsThe 1-min STS test elicits a substantial but lower cardiorespiratory response compared to a maximal cycle ergometry CPET. While PowerSTS and STS repetitions are both valid outcome measures of functional capacity, STS repetitions are clinically more practical.Copyright © 2017 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

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