• Michelangelo Bartolo, Mariano Serrao, Zurab Gamgebeli, Marina Alpaidze, Armando Perrotta, Luca Padua, Francesco Pierelli, Giuseppe Nappi, and Giorgio Sandrini.
• NeuroRehabilitation Unit, IRCCS Neurological Mediterranean Institute NEUROMED, Pozzilli, Isernia, Italy; University Center for Adaptive Disorders and Head pain (UCADH), Pavia, Italy. Electronic address: bartolomichelangelo@gmail.com.
• Pain. 2013 Oct 1;154(10):2054-9.

AbstractThe nociceptive withdrawal reflex (NWR), a defensive response that allows withdrawal from a noxious stimulus, is a reliable index of spinal nociception in humans. It has been shown that various kinds of stimuli (emotional, visual, auditory) can modulate the transmission and perception of pain. The aim of the present study was to evaluate, by means of the NWR, the modulatory effect on the spinal circuitry of olfactory stimuli with different emotional valence. The magnitude of the NWR elicited by electrical stimulation of the sural nerve was measured while 18 subjects (9 women, 9 men) smelled pleasant, unpleasant, or neutral odors. The NWR was conditioned by odor probe with interstimulus intervals (ISIs) of 500 ms and 1,500 ms. The magnitude of NWR was significantly greater after the unpleasant odor probe (P <.001) and reduced following the pleasant odor probe (P<.001) at both ISIs. A significant effect of olfactory stimuli on subjective pain ratings were found at both ISIs for pleasant vs unpleasant odors (P<.000), and for both pleasant and unpleasant odors vs neutral and basal conditions (P<.000). No statistical differences in subjective pain ratings at different ISIs were found. Consistent with the notion that NWR magnitude and pain perception can be modulated by stimuli with different emotional valence, these results show that olfactory stimuli, too, can modulate spinal nociception in humans.Copyright © 2013 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

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