• Anesthesia and analgesia · Jul 2008

    The efficacy of dexmedetomidine in patients with noninvasive ventilation: a preliminary study.

    • Shinji Akada, Shinhiro Takeda, Yuko Yoshida, Keiko Nakazato, Masaki Mori, Takashi Hongo, Keiji Tanaka, and Atsuhiro Sakamoto.
    • Department of Anesthesiology and Intensive Care, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
    • Anesth. Analg. 2008 Jul 1;107(1):167-70.

    BackgroundAgitation is associated with failure of noninvasive ventilation (NIV). We investigated the effect of dexmedetomidine in patients with NIV.MethodsThis was a prospective clinical investigation in an intensive care unit. Dexmedetomidine was infused in 10 patients in whom NIV was difficult because of agitation.ResultsRamsay and Richmond Agitation-Sedation Scale scores were maintained at 2.94 +/- 0.94 and -1.23 +/- 1.30, respectively. All patients were successfully weaned from NIV, and the respiratory state was not worsened.ConclusionThis study shows that dexmedetomidine is an effective sedative drug for patients with NIV.

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