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Proc. Natl. Acad. Sci. U.S.A. · Nov 2001
CD5 expression by B lymphocytes and its regulation upon Epstein-Barr virus transformation.
- D Kaplan, D Smith, H Meyerson, N Pecora, and K Lewandowska.
- Department of Pathology, Case Western Reserve University, Biomedical Research Building, Room 926, 2109 Adelbert Road, Cleveland, OH 44106-4943, USA. drk5@po.cwru.edu
- Proc. Natl. Acad. Sci. U.S.A. 2001 Nov 20; 98 (24): 13850-3.
AbstractDim expression of CD5 on human B lymphocytes has been used to delineate B1 and B2 subsets. Nevertheless, others have suggested that the molecule is an activation marker and does not predicate a subset distinction. We have used enzymatic amplification staining, a technology that enhances the resolution of flow cytometric analysis of cell surface molecules by as much as 100-fold, to determine that essentially all human B cells express CD5. Furthermore, we show that this expression is regulated during Epstein-Barr virus transformation.
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