• Robin Paudel, Christine A Trinkle, Christopher M Waters, Lauren E Robinson, Evan Cassity, Jamie L Sturgill, Richard Broaddus, and Peter E Morris.
• Division of Pulmonary, Critical Care, and Sleep Medicine, Mayo Clinic Health System, Franciscan Healthcare in La Crosse, La Crosse, WI, USA. Electronic address: paudel.robin@mayo.edu.
• Am. J. Med. Sci. 2021 Dec 1; 362 (6): 537545537-545.

AbstractMechanical ventilation is a potentially life-saving therapy for patients with acute lung injury, but the ventilator itself may cause lung injury. Ventilator-induced lung injury (VILI) is sometimes an unfortunate consequence of mechanical ventilation. It is not clear however how best to minimize VILI through adjustment of various parameters including tidal volume, plateau pressure, driving pressure, and positive end expiratory pressure (PEEP). No single parameter provides a clear indication for onset of lung injury attributable exclusively to the ventilator. There is currently interest in quantifying how static and dynamic parameters contribute to VILI. One concept that has emerged is the consideration of the amount of energy transferred from the ventilator to the respiratory system per unit time, which can be quantified as mechanical power. This review article reports on recent literature in this emerging field and future roles for mechanical power assessments in prospective studies.Copyright © 2021 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.

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