• NeuroImage · Jul 1998

    Quantitation of regional cerebral blood flow increases in prefrontal cortex during a working memory task: a steady-state arterial spin-tagging study.

    • F Q Ye, A M Smith, V S Mattay, U E Ruttimann, J A Frank, D R Weinberger, and A C McLaughlin.
    • Clinical Brain Disorders Branch, NIMH, National Institutes of Health, Bethesda, Maryland 20892, USA.
    • Neuroimage. 1998 Jul 1; 8 (1): 44-9.

    AbstractSteady-state arterial spin-tagging MRI approaches were used to quantitate regional cerebral blood flow increases in prefrontal cortex during a working memory ("two-back") task in six normal subjects. Statistically significant increases in cerebral blood flow in prefrontal cortex were observed in all six subjects: the average increase in cerebral blood flow in activated prefrontal cortex regions was 22 +/- 5 cc/100 g/min (23 +/- 7%). The results demonstrate that spin-tagging approaches can be used to follow focal activation in prefrontal cortex during cognitive tasks.

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