• Craig M Hales, Rafael Harpaz, M Riduan Joesoef, and Stephanie R Bialek.
• Ann. Intern. Med. 2013 Dec 3; 159 (11): 739-45.

BackgroundIntroduction of a universal varicella vaccine program for U.S. children in 1996 sparked concern that less-frequent exposure to varicella would decrease external boosting of immunity to varicella zoster virus and thereby increase incidence of herpes zoster (HZ).ObjectiveTo determine whether the varicella vaccination program has influenced trends in HZ incidence in the U.S. population older than 65 years.DesignRetrospective study of Medicare claims.SettingMedicare, 1992 through 2010.Participants2 848 765 beneficiaries older than 65 years.MeasurementsAnnual HZ incidence from 1992 through 2010; rate ratios (RRs) for HZ incidence by age, sex, and race or ethnicity; and state-level varicella vaccination coverage.Results281 317 incident cases of HZ occurred. Age- and sex-standardized HZ incidence increased 39% from 10.0 per 1000 person-years in 1992 to 13.9 per 1000 person-years in 2010 with no evidence of a statistically significant change in the rate of increase after introduction of the varicella vaccination program. Before introduction of this program, HZ incidence was higher in women (RR, 1.21 [95% CI, 1.19 to 1.24]) than men and was lower in black persons (RR, 0.51 [CI, 0.48 to 0.53]) and Hispanic persons (RR, 0.76 [CI, 0.72 to 0.81]) than white persons. In a model adjusted for sex, age, and calendar year from 1997 to 2010, HZ incidence did not vary by state varicella vaccination coverage (RR, 0.9998 [CI, 0.9993 to 1.0003]).LimitationUncertain level and consistency of health-seeking behavior and access and uncertain accuracy of disease coding.ConclusionAge-specific HZ incidence increased in the U.S. population older than 65 years even before implementation of the childhood varicella vaccination program. Introduction and widespread use of the vaccine did not seem to affect this increase. This information is reassuring for countries considering universal varicella vaccination.Primary Funding SourceNone.

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