• I Israeli, J Steiner, G Segev, P H Kass, J S Suchodolski, P Sattasathuchana, Y Bruchim, S Yudelevitch, and I Aroch.
• Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel. Dr_Inbar@yahoo.com
• J. Vet. Intern. Med. 2012 Jul 1; 26 (4): 920-8.

BackgroundPepsinogens are proenzymes secreted by gastric chief cells. In humans, their serum concentrations reflect gastric mucosal morphological and functional status.ObjectivesTo evaluate serum canine pepsinogen-A (cPG-A), C-reactive protein (CRP), and canine pancreatic lipase immunoreactivity (cPLI) concentrations in dogs with gastric dilatation-volvulus (GDV).AnimalsSixty-six dogs presented with GDV and 79 healthy controls.MethodsBlood was collected prospectively, and records retrospectively reviewed.ResultsMedian cPG-A concentration was higher in GDV dogs (median, 397 μg/L; range, 37-5,410) compared to controls (median, cPG-A 304 μg/L; range, 18-848; P = .07). Mortality rate in GDV dogs was 22.7%. In nonsurvivors of GDV, median cPG-A was higher compared to survivors (median, 746 μg/L; range, 128-5,409 versus median, 346; range, 36-1,575, respectively; P = .003). The proportion of dogs with increased cPG-A increased with gastric wall damage score (P = .007). An ROC analysis of cPG-A as a predictor of death showed an area under the curve (AUC) of 0.75, higher than lactate (AUC 0.66), and corresponded to a sensitivity and specificity of 53% and 88%, respectively. CRP was increased in 48 dogs (75%), cPLI was >200 μg/L in 26 dogs (39.4%) and >400 μg/L in 12 dogs (18.2%) but both analytes had no association with outcome.ConclusionsPresurgical cPG-A concentration was positively and significantly associated with gastric wall lesion severity, but, based on ROC analysis, it was only a moderate outcome predictor. CRP and cPLI were commonly increased in dogs with GDV.Copyright © 2012 by the American College of Veterinary Internal Medicine.

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