• Clinics · Sep 2014

    Indomethacin can downregulate the levels of inflammatory mediators in the hippocampus of rats submitted to pilocarpine-induced status epilepticus.

    • Michele Juliane Vieira, Sandra Regina Perosa, Gustavo Adolfo Argaãaraz, José Antônio Silva, Esper Abrão Cavalheiro, and Graça Naffah-MazzacorattiMaria daMdDepartamento de Neurologia/Neurocirurgia, Universidade Federal de São Paulo, São Paulo, SP, Brazil..
    • Departamento de Neurologia/Neurocirurgia, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
    • Clinics (Sao Paulo). 2014 Sep 1; 69 (9): 621626621-6.

    ObjectiveRefractory status epilepticus is one of the most life-threatening neurological emergencies and is characterized by high morbidity and mortality. Additionally, the use of anti-inflammatory drugs during this period is very controversial. Thus, this study has been designed to analyze the effect of a low dose of indomethacin (a COX inhibitor) on the expression of inflammatory molecules.MethodThe hippocampus of rats submitted to pilocarpine-induced long-lasting status epilepticus was analyzed to determine the expression of inflammatory molecules with RT-PCR and immunohistochemistry.ResultsCompared with controls, reduced levels of the kinin B2 receptors IL1β and TNFα were found in the hippocampus of rats submitted to long-lasting status epilepticus and treated with indomethacin.ConclusionsThese data show that low doses of indomethacin could be employed to minimize inflammation during long-lasting status epilepticus.

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