• Diagn. Microbiol. Infect. Dis. · Nov 2010

    Randomized Controlled Trial

    Comparison of 30-min and 3-h infusion regimens for imipenem/cilastatin and for meropenem evaluated by Monte Carlo simulation.

    • Lois S Lee, Martina Kinzig-Schippers, Anne N Nafziger, Lei Ma, Fritz Sörgel, Ronald N Jones, George L Drusano, and Joseph S Bertino.
    • Bassett Healthcare, Cooperstown, NY 13326, USA.
    • Diagn. Microbiol. Infect. Dis. 2010 Nov 1; 68 (3): 251-8.

    AbstractImipenem/cilastatin and meropenem are carbapenem antibiotics that are infused intravenously (IV) over 30 to 45 min. We evaluated probability of target attainment and cumulative probability of target attainment of 30-min and 3-h infusions for imipenem/cilastatin and meropenem. Eighteen healthy adults in a randomized, 4-phase, crossover study received 1000 mg of imipenem/cilastatin or meropenem as a single-dose IV over 30 min or 3 h. A population pharmacokinetics analysis using a 2-compartment IV infusion model was performed. Monte Carlo simulations using various dosage regimens at steady-state and 30-min and 3-h infusion rates were performed to evaluate the probabilities of attaining 20% (bacteriostatic), 30%, and 40% (maximum kill) time above the MIC. Three-hour infusions of imipenem/cilastatin and meropenem improved the cumulative probability of target attainment for a variety of populations of microorganisms compared to 30-min infusions. Prolonged infusions have the potential to optimize efficacy of imipenem/cilastatin and meropenem.Copyright © 2010 Elsevier Inc. All rights reserved.

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