• Guilhian Leipnitz, Lucila de Bortoli da Silva, Carolina Gonçalves Fernandes, Bianca Seminotti, Alexandre Umpierrez Amaral, Carlos Severo Dutra-Filho, and Moacir Wajner.
• Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, CEP 90035-003, Porto Alegre, RS, Brazil.
• Int. J. Dev. Neurosci. 2010 Jun 1; 28 (4): 297-301.

AbstractThe present work investigated the effects of intrastriatal administration of d-serine on relevant parameters of oxidative stress in striatum of young rats. d-Serine significantly induced lipid peroxidation, reflected by the significant increase of thiobarbituric acid-reactive substances, and significantly diminished the striatum antioxidant defenses, as verified by a decrease of the levels of reduced glutathione and total antioxidant status. Finally, d-serine inhibited superoxide dismutase activity, without altering the activities of glutathione peroxidase and catalase. In contrast, this d-amino acid did not alter sulfhydryl oxidation, a measure of protein oxidative damage. The present data indicate that d-serine in vivo administration induces lipid oxidative damage and decreases the antioxidant defenses in the striatum of young rats. Therefore, it is presumed that this oxidative stress may be a pathomechanism involved at least in part in the neurological damage found in patients affected by disorders in which d-serine metabolism is compromised, leading to altered concentrations of this d-amino acid.Copyright 2010 ISDN. Published by Elsevier Ltd. All rights reserved.

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