• J. Intern. Med. · Aug 2009

    Review

    Modulating T-cell homeostasis with IL-7: preclinical and clinical studies.

    • C M Capitini, A A Chisti, and C L Mackall.
    • Immunology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. capitinic@mail.nih.gov
    • J. Intern. Med. 2009 Aug 1; 266 (2): 141153141-53.

    AbstractInterleukin-7 (IL-7) is required for the development and survival of T cells and plays a critical role in modulating T-cell homeostasis. This review will address current understanding of IL-7 biology, review recent clinical experiences and discuss potential future clinical applications of IL-7, or IL-7 blockade, in the setting of disease.

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