• Br J Anaesth · Nov 2021

    Randomized Controlled Trial

    Effect of Hypotension Prediction Index-guided intraoperative haemodynamic care on depth and duration of postoperative hypotension: a sub-study of the Hypotension Prediction trial.

    • Jimmy Schenk, Marije Wijnberge, Jolanda M Maaskant, Markus W Hollmann, Liselotte Hol, Rogier V Immink, Alexander P Vlaar, Björn J P van der Ster, Bart F Geerts, and Denise P Veelo.
    • Department of Anaesthesiology, Amsterdam UMC, Location Academic Medical Centre, Amsterdam, the Netherlands.
    • Br J Anaesth. 2021 Nov 1; 127 (5): 681-688.

    BackgroundIntraoperative and postoperative hypotension are associated with morbidity and mortality. The Hypotension Prediction (HYPE) trial showed that the Hypotension Prediction Index (HPI) reduced the depth and duration of intraoperative hypotension (IOH), without excess use of intravenous fluid, vasopressor, and/or inotropic therapies. We hypothesised that intraoperative HPI-guided haemodynamic care would reduce the severity of postoperative hypotension in the PACU.MethodsThis was a sub-study of the HYPE study, in which 60 adults undergoing elective noncardiac surgery were allocated randomly to intraoperative HPI-guided or standard haemodynamic care. Blood pressure was measured using a radial intra-arterial catheter, which was connected to a FloTracIQ sensor. Hypotension was defined as MAP <65 mm Hg, and a hypotensive event was defined as MAP <65 mm Hg for at least 1 min. The primary outcome was the time-weighted average (TWA) of postoperative hypotension. Secondary outcomes were absolute incidence, area under threshold for hypotension, and percentage of time spent with MAP <65 mm Hg.ResultsOverall, 54/60 (90%) subjects (age 64 (8) yr; 44% female) completed the protocol, owing to failure of the FloTracIQ device in 6/60 (10%) patients. Intraoperative HPI-guided care was used in 28 subjects; 26 subjects were randomised to the control group. Postoperative hypotension occurred in 37/54 (68%) subjects. HPI-guided care did not reduce the median duration (TWA) of postoperative hypotension (adjusted median difference, vs standard of care: 0.118; 95% confidence interval [CI], 0-0.332; P=0.112). HPI-guidance reduced the percentage of time with MAP <65 mm Hg by 4.9% (adjusted median difference: -4.9; 95% CI, -11.7 to -0.01; P=0.046).ConclusionsIntraoperative HPI-guided haemodynamic care did not reduce the TWA of postoperative hypotension.Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.

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