• Rinki Murphy, Alistair W Stewart, Irene Braithwaite, Richard Beasley, Robert J Hancox, Edwin A Mitchell, and ISAAC Phase Three Study Group.
• Department of Medicine, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.
• Obesity (Silver Spring). 2015 May 1; 23 (5): 1030-8.

ObjectiveParacetamol has the potential to also promote weight gain by indirect activation of cannabinoid receptors. The association between paracetamol use in the first 12 months of life or recent high use and BMI in children and adolescents was investigated.MethodsParacetamol use in the first 12 months of life (reported by parents/guardians of 6- and 7-year-olds) or in the past 12 months (reported by parents/guardians of 6- and 7-year-olds or self-reported by adolescents aged 13-14) was examined in relation to BMI in a large multicentre cross-sectional study (2000-2003). Linear regression results were adjusted for whether height and weight were reported or measured, age, sex, country gross national income, study centre, maternal smoking, and recent wheeze.ResultsData were available from 76,216 children (18 countries) and 188,469 adolescents (35 countries). BMI was +0.07 kg/m2 higher in children with early life paracetamol exposure, from affluent countries only. Frequent recent paracetamol use was associated with higher BMI (+0.17 kg/m2, P < 0.0001) among adolescents from affluent countries only, but not in children (P = 0.41).ConclusionsParacetamol may be causally related to increased BMI; alternatively, the association may be explained by lifestyle or other factors that correlate with paracetamol use in affluent countries.© 2015 The Obesity Society.

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