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- Makoto Itoh, Yasuhito Sako, Sonoyo Itoh, Yuji Ishikawa, Hiromitsu Akabane, Kazuhiro Nakaya, Fumiaki Nagaoka, and Akira Ito.
- Department of Infection and Immunology, Aichi Medical University School of Medicine, Nagakute, Aichi 480-1195, Japan. Electronic address: macitoh@aichi-med-u.ac.jp.
- Parasitol. Int. 2013 Dec 1; 62 (6): 514-6.
AbstractAlveolar echinococcosis (AE) is one of the most lethal zoonotic parasitic infections. The diagnosis is based on the combination of the abdominal imaging including CT, MRI and PET, and serology. To develop a new diagnostic tool for AE with urine as samples, mouse-Echinococcus multilocularis (Em) model and then human cases were studied. The antibody levels of urine and serum samples from the infected mice and AE cases were well correlated with each other. The sensitivity and specificity of the method with urine were 91% and 98%, respectively, when IgG4 to crude Em was examined. Comparing with serum samples, the collection of urine is easier and safer and the urine diagnostic tool makes surveys of this silent disease easier. © 2013.
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