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- Shinya Kawamoto, Toshihiro Abe, Katsuhiro Nagahori, Atsunori Yoshino, Akiko Fujii, Yuko Ono, Yoshihiko Ueda, and Tetsuro Takeda.
- Department of Nephrology, Dokkyo Medical University, Saitama Medical Center, Japan.
- Intern. Med. 2022 Jul 1; 61 (13): 2007-2012.
AbstractA 50-year-old Japanese woman with anti-melanoma differentiation-associated gene 5 antibody (anti-MDA5 antibody)-positive dermatomyositis presenting with rapidly progressive interstitial pneumonia was treated with corticosteroids and cyclosporine. She developed nephrotic syndrome during the treatment regimen with corticosteroids and cyclosporine. A kidney biopsy revealed a thrombotic microangiopathy (TMA) glomerular lesion. Anti-MDA5 antibody-positive dermatomyositis is prone to severe interstitial lung disease (ILD) and is often exacerbated and refractory to treatment. Renal symptoms might be due to TMA of the kidney, and this may be a sign that more intensive treatment is needed. Patients sometimes develop acute kidney injury, which may be due to the TMA.
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