• Internal medicine · Jan 2009

    Comparative Study

    Influence of age and nutritional status on glycated albumin values in hemodialysis patients.

    • Tomonari Okada, Toshiyuki Nakao, Hiroshi Matsumoto, Tamami Yamanaka, Yume Nagaoka, and Tokiyo Tamekuni.
    • Department of Nephrology, Tokyo Medical University, Tokyo. t-okada@tokyo-med.ac.jp
    • Intern. Med. 2009 Jan 1; 48 (17): 149514991495-9.

    ObjectiveSeveral studies have shown glycated albumin (GA) to be a more accurate glycemic marker than HbA(1c) in diabetic patients with end-stage renal disease (ESRD). However GA values are influenced by several factors associated with albumin turnover independent of glycemia. We tried to clarify the factors other than glycemic control affecting GA values in ESRD patients.Patients And MethodsWe examined the associations between GA values and several clinical variables related to albumin metabolism in 41 non-diabetic patients on maintenance hemodialysis.ResultsAlthough there were no significant correlations between glucose, albumin, and GA values, there were significant correlations between age, cholinesterase (ChE) values, BMI, and GA values (r=0.515, p=0.0004, r=-0.394, p=0.010, r=-0.327, p=0.036). Stepwise multivariate regression analysis showed that age and ChE values were significant independent variables associated with GA values (beta=0.479, -0.343, R(2)=0.382).ConclusionGA values are influenced by age and nutritional status independent of glycemia in non-diabetic ESRD patients. We should be aware of factors other than glycemic control affecting GA values.

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