• Zhongguo Shi Yan Xue Ye Xue Za Zhi · Feb 2019

    [Clinical Application of R-ISS Staging System in 412 Newly Diagnosed Patients with Multiple Myeloma].

    • Hai-Min Chen, Wei Wei, Rong Peng, Hao-Tian Shi, Xiao-Ling Chen, Li-Xia Wu, Nian Zhou, and Fan Zhou.
    • Department of Hematology, Zhabei Branch of Changzheng Hospital, The Second Military Medical University, Shanghai 200070, China.
    • Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2019 Feb 1; 27 (1): 110-114.

    ObjectiveTo evaluate the prognostic value of R-ISS staging system in patients with newly diagnosed multiple myeloma (NDMM).MethodsThe Chinical data of 412 patients with NDMM in our hospital from May 2010 to May 2016 were retrospectively analyzed. All the patients received conventional chemotherapy or thalidomide or bortezomib-based chemotherapy. All the patients with NDMM were divided into R-ISS-Ⅰ, R-ISS-Ⅱ and R-ISS-Ⅲ groups according to R-ISS staging system on the basis of ISS staging system, cytogenetics and LDH level. The progression-free survival (PFS) time and overall survival(OS) of different groups were compared.ResultsAmong all 412 patients, 76 were rated as R-ISS-Ⅰ, 259 as R-ISS-Ⅱ and 77 as R-ISS-Ⅲ. The median PFS time in 3 groups were 44, 25 and 14 months respectively (P<0.01). The median OS time of the 3 groups were not reached 54 and 25 months respectively (P<0.01). Further analysis also found that statistically different survival associated with different R-ISS groups in the conventional chemotherapy group (P<0.05), bortezomib-based chemotherapy group (P<0.01), thalidomide-based chemotherapy group (P<0.01), transplantation group (P<0.05), different-age stratified group (≤65y P<0.01, 66-75y P<0.01,≥76y P<0.01), damaged renal function group (P<0.01) and extramedullary infiltration group (P<0.01).ConclusionPFS and OS in the patients with multiple myeloma were different among three distrinct R-ISS stages. The R-ISS staging system has important clinical significance for the prognosis evaluation of multiple myeloma.

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