• Aroma Agape Gopalai, Shen Yang Lim, Zariah Abdul Aziz, Soo Kun Lim, Li Ping Tan, Yip Boon Chong, Chong Tin Tan, Santhi Puvanarajah, Shanti Viswanathan, Rishikesan Kuppusamy, Ai Huey Tan, Thien Thien Lim, Gaik Bee Eow, Mohamed Ibrahim Norlinah, Hui Hua Li, Yi Zhao, and Azlina Ahmad-Annuar.
• Department of Biomedical Science, Faculty of Medicine, University of Malaya, Malaysia.
• Ann Acad Med Singap. 2013 May 1; 42 (5): 237-40.

IntroductionThe G2385R and R1628P LRRK2 gene variants have been associated with an increased risk of Parkinson's disease (PD) in the Asian population. Recently, a new LRRK2 gene variant, A419V, was reported to be a third risk variant for PD in Asian patients. Our objective was to investigate this finding in our cohort of Asian subjects.Materials And MethodsEight hundred and twenty-eight subjects (404 PD patients, and 424 age and gender-matched control subjects without neurological disorders) were recruited. Genotyping was done by Taqman® allelic discrimination assay on an Applied Biosystems 7500 Fast Real-Time PCR machine.ResultsThe heterozygous A419V genotype was found in only 1 patient with PD, compared to 3 in the control group (0.4% vs 1.3%), giving an odds ratio of 0.35 (95% confidence interval (CI), 0.01 to 3.79; P = 0.624).ConclusionA419V is not an important LRRK2 risk variant in our Asian cohort of patients with PD. Our data are further supported by a literature review which showed that 4 out of 6 published studies reported a negative association of this variant in PD.

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