• Der Radiologe · Mar 2015

    [Pulmonary manifestations of connective tissue diseases].

    • B Rehbock.
    • Praxis für Diagnostische Radiologie - Spezialgebiet Lunge, Bismarckstr. 45-47, 10627, Berlin, Deutschland, b.rehbock@radiologie-lunge-berlin.de.
    • Radiologe. 2015 Mar 1; 55 (3): 241-54; quiz 255.

    AbstractSystemic autoimmune diseases are responsible for about 25% of all deaths due to interstitial lung disease; therefore, an early identification of patients with pulmonary manifestation changes the management. Detection, differential diagnostic classification and staging of the pneumological pattern of findings are largely based on high-resolution computed tomography (HR-CT). The main differential diagnostic challenges are interstitial manifestations which present with radiological-histopathological phenotypes of interstitial pneumonia. The most common form of interstitial pulmonary reaction form of connective tissue diseases is the nonspecific interstitial pneumonia (NSIP) pattern. In rheumatoid arthritis, a usual interstitial pneumonia (UIP) pattern is dominant. Uncharacteristic reactions of airways and pleura can be the leading symptom or present as accompanying findings. A serious complication is pulmonary hypertension. Drug-induced lung lesions can present with similar HR-CT morphology as connective tissue diseases and can only be differentiated in the temporal and clinical context.

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