• Ginecol Obstet Mex · Mar 2016

    [Maternal serum 25-hydroxy vitamin D levels in the first trimester and adverse gestational outcomes].

    • E Álvarez-Silvares, M Vilouta-Romero, E Borrajo-Hernández, M L Morales-Serrano, and M T Alves-Pérez.
    • Ginecol Obstet Mex. 2016 Mar 1; 84 (3): 150-63.

    BackgroundSome disorders of pregnancy and newborn have been associated with vitamin D deficiency (25 (OH) D) in maternal serum. The pathophysiology of this relationship is unknown today.ObjectiveThe aim of this study was to determine whether serum levels of vitamin D at the beginning of pregnancy are associated with gestational diabetes, hypertensive disorders of pregnancy, preterm birth and fetal growth restriction.Material And MethodWe conducted a prospective cohort study in 370 pregnant women at low obstetric risk randomly selected in our area (latitude 42 ° 20'N). The level of 25-hydroxy vitamin D was determinate between 8 and 14 weeks of pregnancy. We studied the relationship between the status of vitamin D and gestational diabetes, preeclampsia, preterm birth, intrauterine growth restriction and small for gestational age. The statistic analysis was performed using SPSS 15.0 and 3.1 Epidat programs.ResultsThe prevalence of vitamin D deficiency in pregnant women in this serie was 96.8%, 34.6% had severe deficiency. After adjusting for maternal and seasonal variables, we haven't found association between first trimester maternal serum vitamin D levels and pregnancy outcomes studied.ConclusionsThe pregnancy outcome was independent of the first trimester maternal serum 25(OH)D status.

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