• Internal medicine · Feb 2018

    Review Case Reports

    Mycobacterium bovis-induced Aneurysm after Intravesical Bacillus Calmette-Guérin Therapy: A Case Study and Literature Review.

    • Yoshitsugu Higashi, Shigeki Nakamura, Kento Kidani, Kaoru Matumoto, Koyomi Kawago, Junko Isobe, Junichi Kanatani, Yukio Kawagishi, Ippei Sakamaki, and Yoshihiro Yamamoto.
    • Department of Clinical Infectious Diseases, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Japan.
    • Intern. Med. 2018 Feb 1; 57 (3): 429435429-435.

    AbstractMycobacterium bovis infection after intravesical Bacillus Calmette-Guérin (BCG) therapy is rare. A 65-year-old Japanese man with history of bladder cancer and intravesical BCG therapy, presented with low-grade fever. An aneurysm with perianeurysmal fluid was suspected and endovascular aortic repair was performed. After 160 days, he developed blood-streaked sputum and computed tomography images revealed that the perianeurysmal fluid area was increasing in size. A multiplex polymerase chain reaction using sputum identified M. bovis. Treatment with anti-tuberculosis drugs reduced the size of the perianeurysmal fluid area. After intravesical BCG therapy, the possibility of M. bovis infection should be considered, thus further investigations are required.

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