• Internal medicine · Sep 2019

    Case Reports

    Primary IgA Vasculitis with Nephritis in a Patient with Rheumatoid Arthritis Diagnosed by Anti-galactose-deficient IgA1 Immunostaining.

    • Kazunori Karasawa, Yuko Iwabuchi, Mizuki Kyoda, Taro Akihisa, Erika Yamaguchi, Shunji Suzuki, Shota Ogura, Tomo Takabe, Yoei Miyabe, Takahiro Kamiyama, Marie Nakano, Shun Manabe, Michiaki Kamiyama, Kenichi Akiyama, Masayo Sato, Keiko Uchida, Kosaku Nitta, and Takahito Moriyama.
    • Department of Nephrology, Tokyo Women's Medical University, Japan.
    • Intern. Med. 2019 Sep 1; 58 (17): 2551-2554.

    AbstractRenal disease is a common complication of rheumatoid arthritis (RA) and can occur secondary to RA or be induced by therapeutic agents. Recently, glomerular deposition of galactose-deficient IgA1 (Gd-IgA1) was identified as a feature of primary IgA vasculitis with nephritis (IgA-VN). We herein report a case of IgA-VN in an RA patient whose disease activity was controlled by treatment with etanercept. To distinguish between primary IgA-VN and secondary IgA-VN caused by RA or etanercept, we performed immunostaining of renal biopsy sections with the Gd-IgA1-specific antibody KM55. Positive KM55 staining confirmed the diagnosis of primary IgA-VN in a patient with RA.

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