• Pain Med · Jul 2022

    Multicenter Study Observational Study

    Prevalence of myofascial pain syndrome and efficacy of trigger point injection in patients with incurable cancer. A multicenter, prospective observational study. (MyCar study).

    • Hiroto Ishiki, Hideaki Hasuo, Yoshinobu Matsuda, Hiromichi Matsuoka, Shuji Hiramoto, Masaki Higuchi, Kohei Yoshida, Akihiro Tokoro, Yutaka Hatano, Tetsuo Hori, Junya Kinkawa, and Masanori Nojima.
    • Department of Palliative Medicine, National Cancer Center Hospital, Tokyo, Japan.
    • Pain Med. 2022 Jul 1; 23 (7): 1259-1265.

    ObjectiveMyofascial pain syndrome (MPS) is caused by overload or disuse of skeletal muscles. Patients with cancer are often forced to restrict their movement or posture for several reasons. The study was conducted to investigate the prevalence and risks of MPS in patients with incurable cancer. The efficacy of trigger point injection (TPI) was also explored.MethodsThis was a multicenter, prospective observational study. Patients with incurable cancer who started receiving specialist palliative care were enrolled. We investigated the MPS in this population and accompanying risk factors for restricting body movement. Pre- and post-TPI pain was also evaluated using a Numerical Rating Scale (NRS) in patients who received TPI. The primary outcome was the prevalence of MPS.ResultsA total of 101 patients were enrolled from five institutions in Japan. Most of the patients (n = 94, 93.1%) had distant metastases, and half of the patients (50, 49.5%) received anticancer treatment. Thirty-nine (38.6%) patients had MPS lesions at 83 sites. Multivariate analysis revealed that the significant risk factor for MPS was poor Performance Status (PS) (odds ratio 3.26; 95% confidence interval [CI] 1.18-9.02, P = .023). We performed TPI for 40 out of 83 MPS lesions. Mean NRS for MPS before TPI was 7.95, which improved to 4.30 after TPI (P < .001).ConclusionsMPS was common in patients with incurable cancer and the risk factor identified in this study was poor performance status. TPI could be a treatment option.© The Author(s) 2021. Published by Oxford University Press on behalf of the American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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