• Wei Chieh Jack Tan, Kenji Inoue, Laila AbdelWareth, Evangelos Giannitsis, Sazzli Kasim, Masayuki Shiozaki, Tar Choon Aw, Federick Cheng, Ho Thuong Dung, Yi-Heng Li, Swee Han Lim, Antonia Anna Lukito, Martin Than, Fang-Yeh Chu, Tom Devasia, Chien-Chang Lee, Arintaya Phrommintikul, Jong-Chan Youn, and Derek P Chew.
• Department of Cardiology, National Heart Centre Singapore.
• Circ. J. 2020 Jan 24; 84 (2): 136-143.

AbstractThe Asia-Pacific Society of Cardiology (APSC) high-sensitivity troponin T (hs-TnT) consensus recommendations and rapid algorithm were developed to provide guidance for healthcare professionals in the Asia-Pacific region on assessing patients with suspected acute coronary syndrome (ACS) using a hs-TnT assay. Experts from Asia-Pacific convened in 2 meetings to develop evidence-based consensus recommendations and an algorithm for appropriate use of the hs-TnT assay. The Expert Committee defined a cardiac troponin assay as a high-sensitivity assay if the total imprecision is ≤10% at the 99th percentile of the upper reference limit and measurable concentrations below the 99th percentile are attainable with an assay at a concentration value above the assay's limit of detection for at least 50% of healthy individuals. Recommendations for single-measurement rule-out/rule-in cutoff values, as well as for serial measurements, were also developed. The Expert Committee also adopted similar hs-TnT cutoff values for men and women, recommended serial hs-TnT measurements for special populations, and provided guidance on the use of point-of-care troponin T devices in individuals suspected of ACS. These recommendations should be used in conjunction with all available clinical evidence when making the diagnosis of ACS.

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