• Chest · May 2022

    Review

    Off-Label Use and Inappropriate Dosing of Direct Oral Anticoagulants in Cardio-pulmonary Disease.

    • Ayman A Hussein, Paulino Alvarez, Grant Reed, and Gustavo A Heresi.
    • Section of Cardiac Pacing and Electrophysiology, Department of Cardiovascular Medicine, Cleveland, OH. Electronic address: husseia@ccf.org.
    • Chest. 2022 May 1; 161 (5): 1360-1369.

    AbstractDirect oral anticoagulants (DOACs) are increasingly used in clinical practice and have become essential in the management of atrial fibrillation and VTE. The enthusiasm for DOACs has fueled the off-label application of these agents in cardiopulmonary disease, and their use has often outpaced the evidence supporting their application. This article reviews the evidence and current off-label use of DOACs in various cardiopulmonary disease states.Copyright © 2022. Published by Elsevier Inc.

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