• Internal medicine · Sep 2022

    Case Reports

    Case of Angioimmunoblastic T-cell Lymphoma Presenting as a Methotrexate-associated Lymphoproliferative Disorder with Extreme Peripheral Blood Plasmacytosis.

    • Hiroyuki Murakami, Masanori Makita, Tatsunori Ishikawa, Takanori Yoshioka, Keina Nagakita, Yoko Shinno, Tadashi Yoshino, Yoshinobu Maeda, and Kazutaka Sunami.
    • Department of Hematology, National Hospital Organization Okayama Medical Center, Japan.
    • Intern. Med. 2022 Sep 1; 61 (17): 2655-2660.

    AbstractA 74-year-old man was admitted to our hospital because of systemic lymphadenopathy, weight loss, and a fever at night that had persisted for approximately 1 month. Blood tests revealed extreme peripheral blood plasmacytosis and hypergammaglobulinemia. A lymph node biopsy showed angioimmunoblastic T-cell lymphoma (AITL). Based on the history of methotrexate (MTX) administration, the established diagnosis was MTX-associated lymphoproliferative disorder (MTX-LPD). After MTX was discontinued, the lymphadenopathy spontaneously regressed and the plasmacytosis disappeared. He had no disease progression for three years. We found that AITL as an MTX-LPD can cause plasmacytosis, and the prognosis of this disease may not be poor.

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