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Case Reports
Erdheim-Chester Disease Involving the Central Nervous System with Latent Toxoplasmosis.
- Tomoya Wadayama, Mikito Shimizu, Ikko Kimura, Kousuke Baba, Goichi Beck, Seiichi Nagano, Ryo Morita, Hidenori Nakagawa, Michinori Shirano, Tetsushi Goto, Kazumi Norose, Kenji Hikosaka, Shigeo Murayama, and Hideki Mochizuki.
- Department of Neurology, Osaka University Graduate School of Medicine, Japan.
- Intern. Med. 2022 Sep 1; 61 (17): 266126662661-2666.
AbstractErdheim-Chester disease (ECD) is a rare, non-Langerhans cell histiocytosis characterized by the infiltration of foamy histiocytes into multiple organs. We herein report a case of ECD with central nervous system (CNS) involvement in a 63-year-old man who also presented a positive result for Toxoplasma gondii nested polymerase chain reaction testing of cerebrospinal fluid. Since anti-Toxoplasma treatment proved completely ineffective, we presumed latent infection of the CNS with T. gondii. This case suggests the difficulty of distinguishing ECD with CNS involvement from toxoplasmic encephalitis and the possibility of a relationship between the pathogeneses of ECD and infection with T. gondii.
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