• Christopher M Callahan, Malaz A Boustani, Arlene A Schmid, Michael A LaMantia, Mary G Austrom, Douglas K Miller, Sujuan Gao, Denisha Y Ferguson, Kathleen A Lane, and Hugh C Hendrie.
• From Indiana University Center for Aging Research, Indiana University School of Medicine, Regenstrief Institute, and Indiana Alzheimer Disease Center, Indianapolis, Indiana, and Colorado State University, Fort Collins, Colorado.
• Ann. Intern. Med. 2017 Feb 7; 166 (3): 164171164-171.

BackgroundAlzheimer disease results in progressive functional decline, leading to loss of independence.ObjectiveTo determine whether collaborative care plus 2 years of home-based occupational therapy delays functional decline.DesignRandomized, controlled clinical trial. (ClinicalTrials.gov: NCT01314950).SettingUrban public health system.Patients180 community-dwelling participants with Alzheimer disease and their informal caregivers.InterventionAll participants received collaborative care for dementia. Patients in the intervention group also received in-home occupational therapy delivered in 24 sessions over 2 years.MeasurementsThe primary outcome measure was the Alzheimer's Disease Cooperative Study Group Activities of Daily Living Scale (ADCS ADL); performance-based measures included the Short Physical Performance Battery (SPPB) and Short Portable Sarcopenia Measure (SPSM).ResultsAt baseline, clinical characteristics did not differ significantly between groups; the mean Mini-Mental State Examination score for both groups was 19 (SD, 7). The intervention group received a median of 18 home visits from the study occupational therapists. In both groups, ADCS ADL scores declined over 24 months. At the primary end point of 24 months, ADCS ADL scores did not differ between groups (mean difference, 2.34 [95% CI, -5.27 to 9.96]). We also could not definitively demonstrate between-group differences in mean SPPB or SPSM values.LimitationThe results of this trial are indeterminate and do not rule out potential clinically important effects of the intervention.ConclusionThe authors could not definitively demonstrate whether the addition of 2 years of in-home occupational therapy to a collaborative care management model slowed the rate of functional decline among persons with Alzheimer disease. This trial underscores the burden undertaken by caregivers as they provide care for family members with Alzheimer disease and the difficulty in slowing functional decline.Primary Funding SourceNational Institute on Aging.

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