• Arch Int Pharmacodyn Ther · Nov 1989

    Lack of importance of caffeine as an analgesic adjuvant of dipyrone in mice.

    • J Fialip, A Porteix, H Marty, A Eschalier, and P Duchêne-Marullaz.
    • Laboratoire de Pharmacologie et Pharmacie Clinique, Faculté de Pharmacie, INSERM U195, Faculté de Médecine, Clermont-Ferrand, France.
    • Arch Int Pharmacodyn Ther. 1989 Nov 1;302:86-95.

    AbstractThe analgesic effect of caffeine used alone and in combination with dipyrone and butalbital was evaluated after oral administration in mice, using two different pain tests: the hot plate test and the phenylbenzoquinone-induced writhing test. Neither caffeine (5 to 200 mg/kg) nor butalbital (10 and 20 mg/kg) (20 mg/kg was the highest dose that did not induce sleep) produced a significant antinociceptive effect, whereas dipyrone was active from 400 mg/kg in the hot plate test and from 50 mg/kg in the writhing test. The scores obtained with the combinations were not different from those of the dipyrone-treated group, except for the butalbital-dipyrone combination. Thus caffeine is not an analgesic adjuvant in mice; its presence in the combination studied appears to be justifiable only insofar as it inhibited the sedative effect of butalbital.

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