• Internal medicine journal · Apr 2011

    Review Case Reports

    Multiple myeloma presenting with a fever of unknown origin and development of thrombotic thrombocytopenic purpura post-bortezomib.

    • H Moore and K Romeril.
    • Department of Haematology, Wellington Hospital, Wellington, New Zealand.
    • Intern Med J. 2011 Apr 1; 41 (4): 348-50.

    AbstractMultiple myeloma rarely presents with a fever of unknown origin and diagnosis may be delayed. We describe a case of myeloma presenting in this way with raised serum-free light chains and TP53 deletion on cytogenetics. The patient developed thrombotic thrombocytopenia purpura (TTP) following bortezomib therapy but recovered spontaneously and was successfully re-challenged. We believe this is only the second case to describe this phenomenon post-bortezomib and the first to rechallenge the patient successfully without further recurrence of TTP. Possible mechanisms for this successful rechallenge are discussed.© 2011 The Authors. Internal Medicine Journal © 2011 Royal Australasian College of Physicians.

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