• Stella Maris Lins Terena, FernandesKristianne Porta SantosKPFull Professor, Rehabilitation Sciences and Biophotonics Applied to Health Sciences, Uninove, São Paulo, SP, Brazil., Sandra Kalill Bussadori, DeanaAlessandro MeloAMFull Professor, Biophotonics Applied to Health Sciences, Uninove, São Paulo, SP, Brazil., and Raquel Agnelli Mesquita-Ferrari.
• Doctoral Student in Biophotonics Applied to Health Sciences, Universidade Nove de Julho (Uninove), São Paulo, SP, Brazil.
• Rev Assoc Med Bras (1992). 2017 Feb 1; 63 (2): 164-172.

Objective:The aim was to evaluate the effectiveness of the experimental synergists muscle ablation model to promote muscle hypertrophy, determine the period of greatest hypertrophy and its influence on muscle fiber types and determine differences in bilateral and unilateral removal to reduce the number of animals used in this model.Method:Following the application of the eligibility criteria for the mechanical overload of the plantar muscle in rats, nineteen papers were included in the review.Results:The results reveal a greatest hypertrophy occurring between days 12 and 15, and based on the findings, synergist muscle ablation is an efficient model for achieving rapid hypertrophy and the contralateral limb can be used as there was no difference between unilateral and bilateral surgery, which reduces the number of animals used in this model.Conclusion:This model differs from other overload models (exercise and training) regarding the characteristics involved in the hypertrophy process (acute) and result in a chronic muscle adaptation with selective regulation and modification of fast-twitch fibers in skeletal muscle. This is an efficient and rapid model for compensatory hypertrophy.

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