• Anesthesia and analgesia · Sep 1988

    The pharmacokinetics of bupivacaine when injected intra-articularly after knee arthroscopy.

    • J A Katz, C S Kaeding, J R Hill, and T K Henthorn.
    • Department of Orthopedic Surgery, Northwestern University Medical Center, Chicago, Illinois.
    • Anesth. Analg. 1988 Sep 1; 67 (9): 872-5.

    AbstractBupivacaine pharmacokinetics were determined in 11 patients receiving the drug intra-articularly after knee arthroscopy performed under general anesthesia. Forty ml 0.25% bupivacaine was given at the end of surgery and the thigh tourniquet was released 2 to 3 minutes after injection. Blood samples were obtained up to 5 hours after tourniquet release and plasma bupivacaine concentrations were determined. Pharmacokinetic parameters determined were (mean +/- SD): volume of distribution (Vd beta) 206 +/- 88 L, clearance (Cl) 0.816 +/- 0.378 L/min, terminal half-life (T1/2) beta 189 +/- 84 minutes, absorption rate constant (ka) 9.92 +/- 6.79/min, estimated peak plasma concentrations (Cpmax) 0.48 +/- 0.20 micrograms/mL, and time to peak concentration (tmax) 43.4 +/- 23.1 minutes. Results indicate that injections of 100 mg bupivacaine intra-articularly after knee arthroscopy produce peak blood concentrations within the first hour after surgery, and that these will be well below concentrations associated with toxic reactions. Peak concentrations can be minimized with shorter tourniquet inflation times and with longer intervals between injection and tourniquet release.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…