• Internal medicine · Jan 2012

    Case Reports

    Poorly differentiated neuroendocrine carcinoma of the pancreas responsive to combination therapy with gemcitabine and S-1.

    • Mitsuyoshi Yamamoto, Koichiro Miyagawa, Masaaki Hiura, Masashi Taguchi, Yasuyuki Kihara, Shintaro Abe, Shohei Shimajiri, and Masaru Harada.
    • The Third Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Japan.
    • Intern. Med. 2012 Jan 1; 51 (7): 727732727-32.

    AbstractPoorly differentiated neuroendocrine carcinoma is a very rare malignancy, but it is characterized by agressive histological features and a poor clinical prognosis. We report a 42-year-old man who had poorly differentiated neuroendocrine carcinoma of the pancreas with multiple liver metastases. We administrated combined chemotherapy with S-1 and gemcitabine. This treatment was efficacious and well tolerated, and then this patient obtained objective partial response for 7 months and survived for 13 months after the diagnosis. This case suggests that S-1 and gemcitabine combination produce beneficial responses for patients with this disease.

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