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- Miwa Kurimoto, Takashi Sonoki, Yasushi Nakamura, Yasuhide Yamamoto, Yoshimasa Maeda, Kodai Kuriyama, Toshiki Mushino, Hiroki Hosoi, Shogo Murata, Masaya Shimanuki, Kazuo Hatanaka, Nobuyoshi Hanaoka, Jun Kato, and Hideki Nakakuma.
- Department of Hematology/Oncology, Wakayama Medical University, Japan.
- Intern. Med. 2014 Jan 1; 53 (6): 581-5.
AbstractA 57-year-old Japanese man was admitted to our hospital with diarrhea, weight loss and malabsorption. Due to a high serum IgA level, we suspected α-heavy chain disease (α-HCD). However, no monoclonal IgA was detected on protein electrophoresis or immunofixation. Immunohistochemical staining of intestinal biopsy specimens showed proliferation of CD138(+)IgA(+) cells, compatible with a diagnosis of α-HCD. Most α-HCD patients exhibit M-proteins in the serum on electrophoresis or immunoelectrophoresis; however, some patients lack detectable M-proteins, similar to our patient. Therefore, when α-HCD is suspected based on the clinical features, immunohistochemistry is required to make a diagnosis.
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