• Cheng-cheng Guo, Li-xiang Wang, Hui-liang Liu, Wei-wei Dou, Ya-hua Liu, Li-zhi Ma, Kun Sun, Wen-jun Ma, and Xiao-dong Guo.
• Xuzhou Medical College, Jiangsu, China.
• Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2013 Feb 1;25(2):96-8.

ObjectiveTo determine whether interrupted abdominal aorta compression-cardiopulmonary resuscitation (IAAC-CPR), as a new cardiopulmonary resuscitation (CPR) method, can improve resuscitation effects on rabbits with cardiac arrest (CA).MethodsTwenty-eight New Zealand rabbits were randomly divided into two groups in equal number (n=14), and they were resuscitated either by standard CPR (STD-CPR, external chest compression) or by IAAC-CPR (abdominal aorta compression at intermission of external chest compression). CA model was reproduced by injection of iced-potassium chloride, and it was maintained for 3 minutes before resuscitation. Electrocardiogram (ECG), hemodynamic indexes were monitored continuously. Aortic systolic pressure and right atrial pressure at baseline and during resuscitation were recorded. Mean arterial pressure (MAP), coronary perfusion pressure (CPP) and recovery of spontaneous circulation (ROSC) indexes were compared between two groups.ResultsCompared with STD-CPR group, MAP within 2 minutes of resuscitation (without drugs intervention) in the IAAC-CPR group was significantly increased (30 s: 46.0±12.6 mm Hg vs. 30.0±12.2 mm Hg, 60 s: 57.0±15.6 mm Hg vs. 31.9±9.7 mm Hg, 90 s: 61.9±14.4 mm Hg vs. 36.0±9.8 mm Hg, 120 s: 63.1±12.6 mm Hg vs. 37.8±11.1 mm Hg, all P<0.05), and CPP was also significantly increased (30 s: 29.9±17.4 mm Hg vs. 14.1±11.0 mm Hg, 60 s: 43.1±22.4 mm Hg vs. 14.3±9.8 mm Hg, 90 s: 46.7±20.1 mm Hg vs. 15.9±7.7 mm Hg, 120 s: 50.5±21.0 mm Hg vs. 17.3±9.9 mm Hg, all P<0.05), the time of ROSC was earlier (212.1±43.4 s vs. 307.3±51.2 s, P<0.05), and successful resuscitation rate was significantly higher (85.7% vs. 42.8%, P<0.05). However, there were no statistical differences in ROSC rate and the survivor rate at 24 hours and 48 hours between the two groups, though they were increased. No abdominal organs injury was found in all animals by postmortem study.ConclusionAbdominal aorta compression in the intermittent period of chest compression (IAAC-CPR) increases MAP, CPP and the successful rate of resuscitation, thus improves the outcome.

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