• Karthik Raghunathan, Daryl Kerr, Ying Xian, Grace McCarthy, Robert Habib, Alina Nicoara, Shuaiqi Zhang, J Scott Rankin, and Andrew D Shaw.
• Duke University Medical Center, Durham, NC. Electronic address: Karthik.Raghunathan@duke.edu.
• J. Cardiothorac. Vasc. Anesth. 2022 Sep 1; 36 (9): 3529-3542.

ObjectiveTo examine the association/effect of intraoperative cerebral oximetry (CeOx) on major organ morbidity and mortality (MOMM) after adult cardiac surgery.DesignA retrospective, multicenter cohort study.SettingPatients treated at any hospital within the Society of Thoracic Surgeons Adult Cardiac Surgery Database between July 1, 2011, and December 31, 2016, with a 30-day postoperative follow-up.ParticipantsIndividuals ≥18 years old undergoing isolated coronary artery bypass graft (CABG) or valve repair or replacement, or any combination of procedures with cardiopulmonary bypass.InterventionsIntraoperative CeOx.Measurements And Main ResultsMOMM includes operative mortality, stroke, renal failure, prolonged mechanical ventilation, deep sternal wound infection, or reoperation for any reason within 30 days. Of 1.19 million patients who met inclusion criteria within 1,180 facilities, ∼30% (n = 361,124) received CeOx versus nonrecipients (n = 838,675) with similar baseline patient characteristics. Using a propensity score-based 1:1 greedy matching method, 99.7% of CeOx recipients (n = 360,285) were matched with nonrecipients. The rates of MOMM were lower with versus without CeOx. The absolute risk reduction translated to a number needed to treat of 227 patients (95% CI: 166-363, p < 0.0001). In sensitivity analyses of prespecified subgroups, the benefit was strongest among patients undergoing aortic valve repair or replacement ± CABG (more than 7 fewer MOMM events per 1,000, p < 0.0001). However, intensive care unit stay >72 hours was higher with CeOx.ConclusionIntraoperative cerebral oximetry is associated with less major organ morbidity and mortality after adult cardiac surgery. A large-scale clinical trial is warranted, given that desaturation is common and correctable.Published by Elsevier Inc.

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